Association of item-level responses to cognitive function index with tau pathology and hippocampal volume in the A4 Study.

ABSTRACT:

Introduction

Alzheimer's disease (AD) has a long preclinical phase in which individuals may accumulate amyloid beta (Aβ) and tau pathology without noticeable cognitive impairment. Subjective cognitive impairment reports can provide early insights into cognitive decline.

Methods

In the A4 Study, 339 cognitively unimpaired, Aβ-positive individuals underwent tau positron emission tomography imaging. Tau status was classified based on medial temporal lobe tau standardized uptake value ratios (tau_MTL). Participants and study partners assessed cognitive changes using the 15-item Cognitive Function Index (CFI) questionnaire. We explored the relationship among tau_MTL, hippocampal volume (HVa), and CFI reports.

Results

Higher tau_MTL was associa

SUBMITTER: Demirsoy I 

PROVIDER: S-EPMC12177208 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature