REACH assessment of humans exposed to chemicals indirectly via the environment: screening modeling in EUSES versus state of the science.

ABSTRACT: The assessment of humans indirectly exposed to chemicals via the environment (HvE) is an assessment element of the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) regulation. The European Union System for the Evaluation of Substances (EUSES) is the default screening tool, aimed at prioritizing chemicals for further refinement/higher tier assessment. This review summarizes the approach used in EUSES, evaluates the state of the science in human exposure modeling via the environment, and identifies areas for further research to strengthen the confidence and applicability of EUSES for assessing HvE. It confirms that EUSES v2.2 does serve as a conservative screening tool for identifying potential human risk due to HvE (via consumption of crops, meat and milk, fish,

SUBMITTER: Verdonck F 

PROVIDER: S-EPMC12177338 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature