Sustainable Graphene Synthesis and Analysis of Graphene-Based PLA Nanocomposites: Impacts of Polymer Functionalization and Potential Applications in Cancer Treatments.

ABSTRACT: Due to their optimized mechanical, physicochemical, and biocompatible properties, poly-(lactic acid) (PLA)-based composites functionalized with graphene have attracted growing interest in the biomedical field. In this study, a nanocomposite was developed by incorporating graphene at different concentrations into a commercial PLA-like resin, processed using the additive manufacturing technique of vat photopolymerization. Cell viability assays using human melanoma (MV3) tumor cells were performed on samples containing 0.1 and 0.3 wt % graphene. The results showed a significant, concentration-dependent inhibition of tumor cell proliferation. In contrast, nontumor cells (MNP-01 and MRC-5) exhibited good biocompatibility with the material, reinforcing the selective behavior of the composite. To

SUBMITTER: Silva Franca AR 

PROVIDER: S-EPMC12177593 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature