Framework for Brain-Derived Dimensions of Psychopathology.

ABSTRACT:

Importance

Psychiatric diagnoses are not defined by neurobiological measures hindering the development of therapies targeting mechanisms underlying mental illness. Research confined to diagnostic boundaries yields heterogeneous biological results, whereas transdiagnostic studies often investigate individual symptoms in isolation.

Objective

To develop a framework that groups clinical symptoms compatible with ICD-10 and DSM-5 according to their covariation and shared brain mechanisms.

Design, setting, and participants

This diagnostic study was conducted in 2 samples, the population-based Reinforcement-Related Behaviour in Normal Brain Function and Psychopathology (IMAGEN) cohort (longitudinal assessments at 14, 19, and 23 years; study duration from March 2010 to the pre

SUBMITTER: Lett TA 

PROVIDER: S-EPMC12177734 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature