Clinical remission in newly diagnosed type 1 diabetes mellitus and HDL function on cholesterol efflux capacity: prospective InLipoDiab1 study.

ABSTRACT:

Summary

Type 1 diabetes mellitus (DM1) is characterized by high serum HDL, which does not translate into a better prognosis. It is probably related to the impaired function of HDL particles. One of the functions of HDL is reverse cholesterol transport (cholesterol efflux capacity, CEC). Beneficial for management and prognosis in DM1 is the occurrence of partial clinical remission (pCR). It is not known whether the changes in CEC are related to the presence of pCR. The aim was to evaluate the relationship between CEC and pCR in newly diagnosed DM1 during 12 months. The analysis comprised 127 adults (68% men) with newly diagnosed DM1. CEC was assessed in UT Southwestern Medical Center by measuring the efflux of radiolabeled cholesterol from murine J774 macrophages to apolipoprotein B

SUBMITTER: Uruska A 

PROVIDER: S-EPMC12177878 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature