Rh-catalysed single-carbon insertion to 1,3-dienes.

ABSTRACT: Herein, we report the first catalytic single-carbon insertion to 1,3-dienes with Rh(ii)-carbynoids. The skeletal editing process is based on the catalytic generation of a Rh-carbynoid that promotes the insertion of a cationic monovalent carbon unit (:⁺C-R) into the C(sp ² )-C(sp ² ) bond of the 1,3-diene, leading to a pentadienyl cation. Regioselective attack on the latter species leads to the formation of multi-substituted 1,3-dienes or 1,4-dienes with a broad range of carbon and heteroatomic nucleophiles.

SUBMITTER: Sarro P 

PROVIDER: S-EPMC12177889 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature