Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study.

ABSTRACT:

Background

Although evidence for exercise-induced changes in neurocognitive biomarkers is emerging, research examining acute responses to different exercise regimes across sex and age is lacking. This study investigated serum concentrations of three neurocognitive biomarkers (i.e., Klotho, brain-derived neurotrophic factor (BDNF), and glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1)) after acute strength and aerobic exercise, along with skeletal muscle gene expression.

Methods

In a within-subjects crossover design, blood samples of 19 young women, 20 young men, and 14 elderly men were taken before, immediately, 3 h and 24 h after one bout of strength training (ST) and high-intensity interval training (HIIT). Muscle biopsies were taken from a subgroup (n = 22) b

SUBMITTER: Bekkos CH 

PROVIDER: S-EPMC12177964 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature