Exploring the genetic diversity of the 3' untranslated region (UTR) of Dengue virus.

ABSTRACT:

Background

Dengue virus (DENV), with its four antigenically distinct serotypes, is the etiological agent of dengue fever, which is endemic in tropical and subtropical regions but has recently spread to previously non-endemic areas such as Europe. Given the growing body of evidence suggesting that sequence diversification in the 3' UTR of DENV contributes to its epidemiological fitness and host adaptation, we conducted phylogenetic and genetic diversity analyses on four DENV 3' UTR datasets (DENV-1, DENV-2, DENV-3 and DENV-4).

Methods

A maximum likelihood phylogenetic analysis was performed using IQ-TREE, and the average evolutionary divergence was estimated using MEGA X. Maximum likelihood analysis combined with genetic distance calculations provided insight into the evoluti

SUBMITTER: Lo Presti A 

PROVIDER: S-EPMC12178008 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature