Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations.

ABSTRACT: Many anesthetics cause loss of consciousness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of these drugs, we examine how anesthetic doses of ketamine and dexmedetomidine affect bilateral oscillations in the prefrontal cortex of nonhuman primates. Both anesthetics increase phase locking in the ventrolateral and dorsolateral prefrontal cortex, within and across hemispheres. However, the nature of the phase locking varies. Neighboring prefrontal subregions within a hemisphere show decreased phase alignment with both drugs. Local analyses within a region suggest that this finding could be explained by broad cortical distance-based effects, such as large traveling waves. In contrast, homologous areas across hemispheres become more aligned in

SUBMITTER: Bardon AG 

PROVIDER: S-EPMC12178116 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature