Deep Transcranial Magnetic Stimulation in Patients With Opioid Use Disorder: A Double-Blind, Placebo-Controlled Randomized Trial.

ABSTRACT: Opioid use disorder (OUD) is a chronic, relapsing brain disorder. The efficacy of brain stimulation methods in the treatment of OUD has been increasingly investigated. However, the efficacy of deep transcranial magnetic stimulation, namely, wide-volume TMS, in the treatment of OUD has not been investigated. The aim of this randomized, double-blind, sham-controlled add-on study was to evaluate the efficacy of wide-volume TMS using a double-cone coil in participants with OUD. A total of 55 OUD patients were recruited and randomized to receive either active or sham TMS. Active wide-volume TMS treatment was applied to the left dorsolateral prefrontal cortex (DLPFC) in the active TMS group using a double-cone coil, twice daily for 2 weeks, at a frequency of 10 Hz. Sham TMS was also applied to t

SUBMITTER: Guldas S 

PROVIDER: S-EPMC12178270 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature