Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate.

ABSTRACT: Babesiosis is a disease brought on by intraerythrocytic parasites of the genus Babesia. Current chemotherapies are accompanied by side effects and parasite relapse. Therefore, it is crucial to develop highly effective drugs against Babesia. Cipargamin (CIP) has shown inhibition against apicomplexan parasites, mainly Plasmodium and Toxoplasma. This study evaluated the growth-inhibiting properties of CIP against Babesia spp. and investigated the mechanism of CIP on B. gibsoni. The half inhibitory concentration (IC₅₀) values of CIP against the in vitro growth of B. bovis and B. gibsoni were 20.2 ± 1.4 and 69.4 ± 2.2 nM, respectively. CIP significantly inhibited the growth of B. microti and B. rodhaini in vivo. Re

SUBMITTER: Li H 

PROVIDER: S-EPMC12178600 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature