Serum concentrations of Krebs von den Lungen-6 as prognostic biomarker in patients with silicosis.

ABSTRACT:

Introduction

KL-6, a pneumocyte derived biomarker, is increased in patients with interstitial lung diseases (ILDs). We aimed to investigate the role of serum KL-6 as a diagnostic and prognostic biomarker in silica-exposed workers.

Material and method

We studied 108 silica-exposed subjects and 25 healthy controls. Chest radiography (CXR), pulmonary function tests, inflammatory markers were collected. Progressive massive fibrosis (PMF) was defined according to the ILO classification. KL-6 was measured in serum by fully automated CLEIA at first presentation at our institution, intended as baseline visit, with a time point from the initial exposure variable for each patient.

Results

PMF was present in 23 subjects. Serum KL-6 levels were significantly higher in subjects wi

SUBMITTER: Smarandescu RA 

PROVIDER: S-EPMC12178848 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature