Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway.

ABSTRACT: Type I diabetes (T1D), also known as juvenile diabetes, is an autoimmune disease that causes gradual destruction of pancreatic cells and leads to intellectual disability, neuropathy, cognitive impairment, and impaired learning ability in children. Despite standard treatment with synthetic human insulin, T1D patients can maintain up to 40% of their insulin-producing islets. PPARγ receptor activation research that aims to restore β-cell biology could help reverse the loss of pancreatic mass that comes with getting older and improve β-cell function. Egyptian RB ethanol extract (RBE), previously reported with PPARγ agonist activity, showed an increase in insulin secretion both in vivo and in INS-1 cells. The exact antidiabetic RBE mechanism is still unclear. The present study aims to investiga

SUBMITTER: Youssef MM 

PROVIDER: S-EPMC12178994 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature