PTX3 as a diagnostic and prognostic biomarker in lung adenocarcinoma: a comprehensive analysis.

ABSTRACT:

Background

Lung cancer remains a leading global cause of mortality, with lung adenocarcinoma (LUAD) as the predominant histological subtype. Current serum biomarkers like carcinoembryonic antigen (CEA) lack specificity, necessitating novel diagnostic targets. Pentraxin 3 (PTX3), a homo-multimeric protein downregulated in malignancies, was evaluated for its diagnostic and prognostic roles in LUAD.

Methods

PTX3 expression was analyzed using TCGA/GEO datasets and clinical serum samples (97 LUAD vs. 40 controls). Diagnostic utility was assessed via ROC curves for PTX3, CEACAM5, and their combination. Prognostic value was determined by Kaplan-Meier and Cox regression. PTX3-associated differentially expressed genes (DEGs) were explored through functional enrichment, tumor microenv

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12179049 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature