Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke - Insights from a proof-of-concept study.

ABSTRACT: Stroke imposes significant global socio-economic burdens, yet the absence of clinically approved anti-ischemic drugs and limited thrombolysis availability underscore the critical need for novel therapeutic target. To identify novel anti-ischemic therapeutic targets, we conducted a comprehensive proteomics analysis subsequent to in vitro ischemia/reperfusion of epithelial cells highly sensitive to oxygen deprivation with and without eIF5A inhibition, a strategy recently acknowledged for its efficacy in alleviating ischemic-anoxic damage. We identified seryl-tRNA synthetase (serRS) as a promising target through several key findings. Initially, we validated its inhibition as highly efficient in reducing cell death in an in vitro model of ischemia/reperfusion. Subsequently, we demonstra

SUBMITTER: Bourourou M 

PROVIDER: S-EPMC12179111 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature