Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities.

ABSTRACT: Sea dragons (Syngnathus) are valuable marine resources with notable interspecific phenotypic similarities and variations in composition and efficacy. This study employed multi-omics technologies to comprehensively analyze and structurally identify the molecular components of six species of Syngnathus, effectively screening interspecific differential markers. Untargeted metabolomics revealed a total of 18 classes and 2264 metabolites, and lipids were found to be the principal differential metabolites. Lipidomics were utilized for in-depth lipid detection, expanding the original 412 lipids detected through metabolomics to 2078 lipids, among which 47 differential metabolites and 138 differential lipids were selected from multi-omics results. The integration of network pharmacology and molecul

SUBMITTER: Wu H 

PROVIDER: S-EPMC12179263 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature