The dynamics of cognitive decline toward Alzheimer's disease progression: Results from ADSP-PHC's harmonized cognitive composites.

ABSTRACT:

Introduction

Accurately assessing the temporal order of cognitive decline across multiple domains is critical in Alzheimer's disease (AD). Existing literature presents controversial conclusions likely due to the use of a single cohort and different analytical strategies.

Methods

Harmonized composite cognitive measures in memory, language, and executive functions from 13 cohorts in the Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) were used. A double anchoring events-based sigmoidal mixed model was developed using time to incident AD diagnosis as the time scale.

Results

In general, decline in memory occurred before decline in language, followed by decline in executive function. This temporal order generally persisted within each s

SUBMITTER: Kang K 

PROVIDER: S-EPMC12179338 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature