Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk.

ABSTRACT:

Background

In this study, we investigated the genetic connections between attention-deficit/hyperactivity disorder (ADHD), migraine (MGN), and multisite chronic pain (MCP). The goal was to identify specific shared biological mechanisms that contribute to the overlap between ADHD and these pain-related conditions.

Methods

We utilized various post-genome-wide association study analyses on summary data from samples ranging between 225,534 and 766,345 individuals. In an independent sample of patients with ADHD and control participants (665 cases and 995 controls), we evaluated MGN and MCP polygenic risk scores (PRSs) in relation to comorbid profiles, symptom severity, and neuroimaging brain scores.

Results

The findings show a strong biological overlap between ADHD and MCP

SUBMITTER: Ciochetti NP 

PROVIDER: S-EPMC12179596 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature