Post-transcriptional regulation of <i>cyclin A</i> and <i>B</i> mRNAs by Bruno 1, Cup, and P-bodies.

ABSTRACT: Cell cycle progression relies on tightly regulated Cyclin synthesis and degradation, with Cyclins A and B activating CDK1 to drive mitosis. Dysregulation of Cyclin levels is linked to tumorigenesis, underscoring the importance of studying cyclin mRNA control for cancer therapy development. Using super-resolution microscopy, we show that cyclin A and cyclin B mRNAs associate with Bruno 1 and Cup in nurse cells, and that depletion of either protein disrupts Cyclin expression and reduces mRNA levels. Both mRNAs also accumulate in Me31B-marked P-bodies; however, Me31B selectively affects cyclin B, causing its stage-specific de-repression and decreased stability, while cyclin A remains unaffected. Loss of Me31B enhances cyclin B mRNA's association with

SUBMITTER: Bayer LV 

PROVIDER: S-EPMC12179632 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature