Single electron/energy transfer photocatalysis: α-/β-switchable synthesis of 3-deoxy-d-manno-oct-2-ulosonic acid <i>O</i>-glycosides.

ABSTRACT: Stereoselective glycosidation of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) has emerged as a focal point in glycoscience, attributed to the burgeoning identification of naturally occurring α- or β-Kdo glycosides within the glycoconjugate structures of various organisms. Nonetheless, advancements in α-/β-switchable stereoselective Kdo O-glycosidation remain scarce due to the complicated synthesis of Kdo donors and the complex chemical environment at the anomeric carbon of Kdo. Herein, inspired by the property that the conditions of the photocatalytic reaction can be facilely controlled and mediated, we report an efficient photocatalytic Ir^III/Cu^II-catalysed Kdo O-glycosidation for the stereoselective synthesis of both α- and β-Kdo O-glycosides with

SUBMITTER: Zhang JD 

PROVIDER: S-EPMC12179690 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature