Differential impact of hepatitis delta virus replication and expression of viral antigens on the cellular kinome profile.

ABSTRACT:

Background

An infection with hepatitis D virus (HDV) is considered the most extreme form of viral hepatitis. Infection with HDV elicits strong increases in inflammation and hepatic injury, therefore pushing liver cirrhosis and development of hepatocellular carcinoma (HCC). Despite this, little is known on how HDV influences the host-cell's equilibrium. As the pathogenesis is majorly driven by host-responses, a deep understanding is required in terms of how signalling cascades are modulated by the virus in order to identify targets for preventive and therapeutic strategies. Accordingly, this study aims to establish the kinome profile for HDAg-expressing and HDV-replicating cells which could serve as base for future research characterizing HDV-host interaction.

Methods

We perf

SUBMITTER: Thiyagarajah K 

PROVIDER: S-EPMC12180150 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature