In-depth analysis of the mode of action of resveratrol: genome-wide characterization of G-quadruplex binding properties.

ABSTRACT:

Background

Resveratrol (RSV) is one of the most studied and used biomolecules, for which many pharmacological effects targeting multiple tissues have been described. However, a common underlying mechanism driving its full pharmacological activity has not been described in detail. G-quadruplexes (G4s) are non-canonical nucleic acid structures found in regulatory genomic locations and involved in controlling gene transcription, telomere maintenance, or genome stability, among others. This study provides a genome-wide characterization of RSV G4-binding properties, explaining its multi-target traits.

Methods

Immunofluorescence assays using a nucleolar and a G4-specific antibody were used to characterize RSV cellular effects on the nucleolus and G4 stabilization. DNA damage and c

SUBMITTER: Soriano-Lerma A 

PROVIDER: S-EPMC12180162 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature