Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD.

ABSTRACT:

Objective

Attention-deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder with a significant genetic component. The latest genome-wide association study (GWAS) meta-analysis of ADHD identified 27 whole-genome significant risk loci in the European population. However, genetic risk factors for ADHD are less well-characterized in the Asian population, especially for low-frequency / rare variants.

Methods

In this study, we aimed to investigate the contributions of both common and low-frequency / rare variants to ADHD in a Hong Kong sample. Our sample comprised 279 cases and 432 controls who underwent genotyping using the Illumina Infinium Global Screening Array. We employed various analytical methods at different levels, while also leveraging multi-omics da

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12180188 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature