Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses.

ABSTRACT:

Introduction

Understanding the intricacies of the host inflammatory response to coronaviruses is essential for developing effective therapeutic strategies to mitigate the severe consequences of these infections. Various coronaviruses can trigger the host immune response, leading to highly similar inflammatory reactions. The mouse hepatitis virus (MHV), which belongs to the same group of beta-coronaviruses as SARS-CoV-2 and induces high pathogenicity in mice, typically serves as a safety model for investigating highly pathogenic coronavirus infections, replication, and virus-host interactions.

Methods

In this study, we conducted a comprehensive analysis of the transcriptome and proteome of mouse bone marrow dendritic cells (BMDCs) infected with MHV.

Results

We characte

SUBMITTER: Ji Y 

PROVIDER: S-EPMC12180443 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature