Genetic abnormalities in catatonia: a systematic review.

ABSTRACT:

Background

Catatonia has many potential underlying causes, but in some patients, no clear etiology is identified, sparking growing interest in its genetic basis. We aimed to provide the first comprehensive synthesis of genetic abnormalities in catatonia.

Methods

In this systematic review (PROSPERO CRD42023455118) we searched MEDLINE All, Embase Classic + Embase, PsycINFO, and AMED up to August 15, 2023, for studies on genetic testing and catatonia phenotyping in all age groups. Catatonia was diagnosed using specified diagnostic criteria or description of clinical features. Risk of bias was assessed using the Joanna Briggs Institute quality assessment tools. Results were summarized with a narrative synthesis.

Results

We included 99 studies involving 8600 individuals. S

SUBMITTER: Conti I 

PROVIDER: S-EPMC12180507 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature