Unraveling Molecular and Functional Responses Across 3 Lung Injury Models to Expand the Donor Lung Pool.

ABSTRACT:

Background

Lung transplantation remains hampered by a scarcity of viable donor lungs, partially attributed to donor lung injuries.

Methods

Three porcine lung injury models were studied: infection-induced using lipopolysaccharide (n = 7), aspiration-induced using endotracheal gastric content (n = 7), and injury using lavage and harmful ventilation (ventilator-induced lung injury; n = 7). Molecular and functional changes from before and after the establishment of lung injury were examined with histopathology, immunohistochemistry, cytokine levels, hemodynamics, and mass spectrometric analysis of lung tissue. The respiratory tract lining fluid was analyzed using exhaled breath particles.

Results

T-cell proliferation and suppression of complement activation were unique to

SUBMITTER: Hirdman G 

PROVIDER: S-EPMC12180699 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature