A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies.

ABSTRACT:

Context

In vitro toxicology studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. INVITES-IN, a tool for assessing the internal validity of in vitro studies, is currently under development. The first step in developing INVITES-IN involves the creation of an "item bank," an overview of study assessment concepts that may be relevant to evaluating the internal validity of in vitro toxicology studies. The item bank and methodology for its creation presented in this manuscript are intended to be a general resource for supporting the development of appraisal tools for in vitro toxicology studies and potentially other study designs.

Methods

We derived the item bank from seven literature sources (one exis

SUBMITTER: Vist GE 

PROVIDER: S-EPMC12180937 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature