Spatial transcriptomics of progression gene signature and tumor microenvironment leading to progression in mycosis fungoides.

ABSTRACT:

Abstract

Mycosis fungoides (MF) is characterized by stepwise evolution from patch to plaque and sometimes to tumor. Identifying patients with early-stage MF who could progress to an advanced stage is challenging. This study investigated changes in transcriptomic expression and the tumor microenvironment associated with MF progression. Spatially resolved transcriptomic profiling was conducted using CD3, CD4, and CD30 morphology markers. In the lymphoma cell area, genes linked to collagen fibril assembly and regulation of interleukin-4 were upregulated as the disease progressed from patch- to plaque-stage MF. Genes involved in the cell cycle and glutamate catabolism were upregulated during the transition from plaque- to tumor-stage MF. Forty-six significant genes that consistently in

SUBMITTER: Choi ME 

PROVIDER: S-EPMC12180985 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature