Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT: Multidomain intervention in type 2 diabetes.

ABSTRACT:

Aims

To identify subgroups who may be more likely to respond well to a multidomain intervention among older adults with type 2 diabetes.

Materials and methods

This study was a secondary analysis of the Japan Multimodal Intervention Trial for Prevention of Dementia. A total 531 participants aged 65-85 years with mild cognitive impairment were randomized into intervention (vascular risk management, exercise, nutritional counseling, and cognitive training) and control (health-related information) groups. The outcome was the change in average Z scores of neuropsychological tests from baseline to 18 months. Interactions between intervention and age (65-74, 75-85 years), memory impairment (amnestic, nonamnestic), HbA1c levels (within, outside target range), or APOE genotype

SUBMITTER: Sugimoto T 

PROVIDER: S-EPMC12181009 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature