Various diseases and conditions are strongly associated with the next-generation epigenetic aging clock CheekAge.

ABSTRACT: Epigenetic aging clocks represent contemporary aging biomarkers that predict age using methylomic data. These models can be categorized as first-generation clocks that estimate chronological age or next-generation clocks that are designed to associate with health, lifestyle, and/or outcomes. Recently, we created a next-generation buccal clock called CheekAge that associates with all-cause mortality risk in older adults. To better understand our model, we collated 25 Infinium MethylationEPIC datasets in the Gene Expression Omnibus database and analyzed the ability of CheekAge and five other well-known clocks to associate with distinct health and disease signals. CheekAge outcompeted every other clock tested by significantly associating with a total of 33 different disease and health variabl

SUBMITTER: Shokhirev MN 

PROVIDER: S-EPMC12181163 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature