Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle.

ABSTRACT: Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves muscle size and function; however, the response to exercise training is variable in older adults. The objective of our study was to determine both the age-independent and age-dependent changes to the transcriptome following progressive resistance exercise training. Skeletal muscle biopsies were obtained before and after 12 weeks of resistance exercise training in 8 young (24 ± 3.3 years) and 10 older (72 ± 4.9 years) men. RNA was extracted from each biopsy and prepared for analysis via RNA sequencing. We performed differential mRNA expression, gene ontology, and gene set enrichment analyses. We report that when comparing post-training vs pre-training 226 mRNAs and 959 m

SUBMITTER: Von Ruff ZD 

PROVIDER: S-EPMC12181168 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature