In-hospital mortality among children and adults hospitalized with COVID-19 in Africa across pre-delta, delta, and omicron SARS-CoV-2 waves.

ABSTRACT:

Background

This study examines in-hospital mortality among children and adults hospitalized with COVID-19 across the pre-Delta, Delta, and Omicron waves in the African region.

Method

We conducted a retrospective cohort study using individual-level data from 520,810 hospitalized children and adults in 13 African countries. Cox proportional hazards regression models were used to assess the impact of SARS-CoV-2 variants on in-hospital mortality.

Findings

Among children, the risk of in-hospital mortality was comparable between pre-Delta and Delta waves (aHR 1.02, 95% CI 0.77-1.35). In adults, mortality increased by 6% during Delta wave compared with pre-Delta wave (aHR 1.06, 95% CI 1.04-1.09). During Omicron wave, mortality risk decreased significantly by 42% in children

SUBMITTER: Inzaule S 

PROVIDER: S-EPMC12181171 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature