CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites.

ABSTRACT: Intestinal epithelial overexpression of the Th17 cell chemoattractant CCL20 is implicated in inflammatory bowel disease and influenced by NOD2 mutations in Crohn's disease. Vitamin D metabolites have been shown to ameliorate inflammatory bowel disease. Considering NOD2 mutations in Crohn's disease, we investigated whether Vitamin D deficiency (serum 25-hydroxyvitamin D concentration < 20 ng/mL) increases circulating CCL20 levels in inflammatory bowel disease patients and healthy controls and whether active 1,25-dihydroxyvitamin D (calcitriol) downregulates systemic and intestinal CCL20 expression. In a cross-sectional study, serum concentrations of CCL20, 25-hydroxyvitamin D, and calcitriol were measured in 170 NOD2-genotyped Crohn's disease patients, 80 ulcerative colitis patients, and 60

SUBMITTER: Stallhofer J 

PROVIDER: S-EPMC12181267 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature