Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection.

ABSTRACT:

Background

The ongoing evolution of SARS-CoV-2, particularly through the emergence of new variants, continues to challenge our understanding of immune protection. While antibody levels correlate with protection against earlier variants such as Alpha and Delta, their relationship with Omicron sub-variants remains unclear.

Methods

To investigate the role of antibody levels and neutralizing activity in preventing breakthrough infections, we analyzed longitudinal SARS-CoV-2 humoral responses and neutralizing activity against the ancestral virus and major emerging variants in a well-characterized cohort of healthcare workers in Spain (N = 405).

Results

We find that antibody levels and neutralization titers are key indicators of protection against SARS-CoV-2, including the

SUBMITTER: Martin Perez C 

PROVIDER: S-EPMC12181274 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature