Cytotoxicity evaluation and metabolomic profiling of Spheciospongia vagabunda-associated fungi corroborated by in silico studies.

ABSTRACT: Cancer incidence continues to increase every year. Scientists strive to search for new anticancer compounds to combat this disease. Appealingly, marine environmental niches are still an untapped scaffold for natural products with chemical and biomedical diversity. Hence, fungi isolated from the Red Sea sponge Spheciospongia vagabunda were explored. Two strains were purified from the sponge and identified, depending on 18 S rRNA gene sequence, as Aspergillus sp. (UR1) and Penicillium sp. (UR2). The obtained fungal extracts were submitted to LC-HR-ESI-MS metabolomics evaluation, which showed notable variation in the chemical profiles of both extracts. The cytotoxic activity was assessed against three cancer cell lines: HepG2 (hepatocellular carcinoma human), MCF7 (breast cancer) and CaCo-2 (

SUBMITTER: Abdelhafez OH 

PROVIDER: S-EPMC12181285 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature