Insights on the neurocognitive mechanisms underlying hippocampus-dependent memory impairment in COVID-19.

ABSTRACT: COVID-19 has been linked to acute and long-term cognitive impairments, including memory and concentration deficits, as well as neuropsychiatric symptoms such as anxiety and depression. However, the neuropathophysiological mechanisms underlying these cognitive and affective changes remain poorly understood. Accumulating evidence points towards neuroinflammation as a potential driver of most acute and post-acute neurofunctional symptoms. In this study, we aimed to comprehensively characterize cognitive impairment associated with COVID-19 using a large online cohort of over 1400 participants, including individuals reporting a previous SARS-CoV-2 infection and individuals who had never been tested positive. Our cognitive test battery covered alertness, executive functions, and episodic long-te

SUBMITTER: Meyer P 

PROVIDER: S-EPMC12181319 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature