Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan.

ABSTRACT: Cognitive frailty is considered a clinical entity associated with a high risk for adverse health outcomes. However, its clinical significance remains poorly understood. This study investigated the association between cognitive frailty and risk for functional disability among community-dwelling older adults. In total, 1,597 Japanese adults aged ≥ 65 years that were free of dementia and functional disability at baseline were prospectively followed for 10 years. Cognitive frailty was defined as the presence of both physical frailty (using Cardiovascular Health Study criteria) and cognitive impairment (Mini-Mental State Examination score < 26 points). Functional disability was identified using Japan's Long-term Care Insurance System database. Cox proportional hazard models were used to estimat

SUBMITTER: Chen S 

PROVIDER: S-EPMC12181443 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature