Depressive intensity, duration, and their associations with cognitive decline: a population-based study in Korea.

ABSTRACT: Existing epidemiological studies have ignored the effect of depressive duration on cognitive decline despite the presence of biological cues and understudied the depression-cognition association in Asian countries in the context of increasing cognitive burden worldwide. We aimed to comprehensively characterize the effects of depressive duration and intensity on cognitive decline at the population level. A total of 6406 individuals from the Korean Longitudinal Study of Aging (KLoSA) from 2010 to 2018 were included to generate four datasets with durations of 2, 4, 6, and 8 years. Depressive intensity was categorized as no, mild, and major depression according to the Center for Epidemiological Studies Depression scale (CES-D10), and duration was measured by the span of consecutive interviews.

SUBMITTER: Lu K 

PROVIDER: S-EPMC12181449 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature