Lung endothelial cell senescence impairs barrier function and promotes neutrophil adhesion and migration.

ABSTRACT: Cellular senescence contributes to inflammation and organ dysfunction during aging. While this process is generally characterized by irreversible cell cycle arrest, its morphological features and functional impacts vary in different cells from various organs. In this study, we examined the expression of multiple senescent markers in the lungs of young and aged humans and mice, as well as in mouse lung endothelial cells cultured with a senescence inducer, suberoylanilide hydroxamic acid (SAHA), or doxorubicin (DOXO). We detected increased levels of p21, γH2AX, and SA-β-Gal and decreased Ki-67 and Lamin B1 in aged lungs and senescent lung endothelial cells. Importantly, the expression of senescent markers was associated with an inflammatory response in aged mouse lungs characterized by neutr

SUBMITTER: Najari Beidokhti M 

PROVIDER: S-EPMC12181458 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature