Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila.

ABSTRACT: Dietary restriction (DR) is widely considered to be one of the most potent approaches to extend healthy lifespan across various species, yet it has become increasingly apparent that DR-mediated longevity is influenced by biological and non-biological factors. We propose that current priorities in the field should include understanding the relative contributions of these factors to elucidate the mechanisms underlying the beneficial effects of DR. Our work conducted in two laboratories represents an attempt to unify DR protocols in Drosophila and to investigate the stochastic effects of DR. Across 64 pairs of survival data (DR/ad libitum, or AL), we find that DR does not universally extend lifespan. Specifically, we observed that DR conferred a significant lifespan extension in only 26.7% (1

SUBMITTER: Mosley OL 

PROVIDER: S-EPMC12181480 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature