A CD8⁺ T Cell Infiltration-Driven Prognostic Signature for Gastric Cancer: Bridging Tumor Immunity and Clinical Outcomes.

ABSTRACT: Background: CD8⁺ T cells play pivotal roles in antitumor immunity, where infiltration levels often correlate with favorable prognosis. However, the functional heterogeneity of CD8⁺ T cell subsets within the gastric cancer (GC) tumor microenvironment (TME)-particularly their divergent impacts on tumor progression, immunotherapy response, and clinical outcomes-remains poorly characterized. Methods: We integrated single-cell RNA sequencing (scRNA-seq) data from 23 GC tissues (GEO: GSE150290) with bulk transcriptomic profiles from TCGA-STAD to dissect CD8⁺ T cell heterogeneity. Analytical pipelines included unsupervised clustering, pseudotime trajectory analysis, and protein-protein interaction (PPI) network construction to identify survival-assoc

SUBMITTER: Qian Y 

PROVIDER: S-EPMC12181657 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature