HVJ-E links Apolipoprotein d to antitumor effects.

ABSTRACT:

Background

Virotherapy eradicates tumors by directly killing cancer cells and causing adjuvant effects. However, the mechanism by which non-replicating virotherapy exerts anti-tumor effects is unclear.

Methods

In this study, we investigated the genes that mediate the anti-tumor effects of ultraviolet (UV)-irradiated Hemagglutinating Virus of Japan envelope (HVJ-E) using RNA sequencing, gene knockout, and a drug-inducible gene expression system. We examined the antitumor effects of Apolipoprotein d (Apod) using genome-wide CRISPR library screening, in situ biotinylation combined with mass spectrometry, flow cytometry, biochemistry, and tumor-bearing mouse models.

Results

Here, we show that HVJ-E represses tumor growth via Irf7-induced Apod expression in tumor cells

SUBMITTER: Ishibashi A 

PROVIDER: S-EPMC12182123 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature