Immunosuppressive microenvironment of liver restrains chemotherapeutic efficacy in triple-negative breast cancer.

ABSTRACT:

Background

Patients with liver metastases of triple-negative breast cancer (TNBC) show poor prognosis compared with other metastases. Chemotherapy is the primary treatment for advanced TNBC. Tumor cell diversity and the tumor microenvironment could affect therapeutic effect. However, whether liver metastases of TNBC exhibit differential chemotherapy efficacy compared with the primary tumors remains inadequately understood. The specific mechanisms that modulate chemotherapy efficacy in liver metastases need further investigation.

Methods

Single-cell RNA sequencing data from public databases were leveraged to contrast the immune profiles of liver metastases and primary tumors in TNBC. Murine models bearing liver tumors or primary tumors of TNBC were used to evaluate chemothera

SUBMITTER: Liu M 

PROVIDER: S-EPMC12182172 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature