EML2 and EML4 splice variants regulate microtubule remodeling during neuronal cell differentiation.

ABSTRACT: Neurons depend on microtubule organization for axon and dendrite formation during differentiation. Yet, our understanding of how microtubules are remodeled during this process is far from complete. Echinoderm microtubule-associated protein-like (EML) is a family of microtubule-associated proteins (MAPs) highly expressed in neuronal cells. Database analysis revealed that EMLs are subject to alternative splicing in their N-terminal regions, leading to the production of one long (L) variant containing a complete N-terminus and TAPE domain, and possibly several short (S) variants with a truncated N-terminal region. We investigated EML4 and EML2 splice variants during SH-SY5Y neuronal cell differentiation, examining their expression, localization, and effects on neurite outgrowth and branching.

SUBMITTER: Marasi V 

PROVIDER: S-EPMC12182296 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature