Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation.

ABSTRACT:

Background

Neuroinflammation is linked to the development of depression. Exposure to the proinflammatory endotoxin lipopolysaccharide (LPS) is associated with a depressive-like phenotype in rodents. However, acute LPS exposure may reflect sickness behavior, and thus the molecular mechanisms and neurobehavioral changes associated with chronic neuroinflammation warrant investigation.

Methods

Using male Sprague Dawley rats (N = 37) we investigated the impact of systemic inflammation, following a single or multiple doses of LPS on neurobehavioral outcomes and brain regional gene expression of inflammatory, neurotrophic and apoptotic markers in the prefrontal cortex, striatum, hippocampus, hypothalamus, midbrain, cortex, and cerebellum.

Results

LPS administration in

SUBMITTER: Pienaar L 

PROVIDER: S-EPMC12182298 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature