ZNFX1 suppresses apoptosis-associated mRNA stability in cardiomyocyte to protect against myocardial infarction.

ABSTRACT: Cardiovascular diseases remain a growing global health burden, with myocardial infarction (MI) persisting as the leading cause of cardiovascular mortality worldwide. Zinc finger NFX1-type containing 1 (ZNFX1), an RNA helicase family member, remains relatively understudied in molecular biology and its role in cardiovascular diseases remains unclear. This study aims to explore the involvement of ZNFX1 in MI and uncover its mechanisms. This research found ZNFX1 was decreased in MI myocardium and hypoxia-treated cardiomyocyte. Overexpression of ZNFX1 significantly attenuated myocardial dysfunction, reduced infarct size, inhibited collagen deposition and alleviated cardiac hypertrophy which was ascribed to MI in mice, whereas knockdown of ZNFX1 produced the opposite effects. Mechanistically, RN

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12182381 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature