Modeling gonorrhea vaccination to find optimal targeting strategies that balance impact with cost-effectiveness.

ABSTRACT: Vaccination for UK men who have sex with men (MSM) at increased gonorrhea risk has been advised, but not yet implemented. Effective targeting is essential for cost-effectiveness, but previously-examined approaches have disadvantages: Vaccination-on-Diagnosis has low coverage (limiting impact), and Vaccination-according-to-Risk requires asking about sexual behavior to identify at-risk individuals, which is not always feasible. We developed a transmission-dynamic model to evaluate novel strategies offering vaccination based on information readily available to clinicians (diagnostic/vaccination history, if the patient is seeking care due to partner notification). Offering vaccination to MSM who are notified partners of gonorrhea cases or were diagnosed themselves in the past 2 years averts 1.

SUBMITTER: Leng T 

PROVIDER: S-EPMC12182581 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature