Pathogen-specific host response in critically ill patients with blood stream infections: a nested case-control study.

ABSTRACT:

Background

Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI).

Methods

RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-specific BSIs. Twenty biomarkers reflecting key host response pathways were measured in blood.

Findings

We included 341 patients, among which 255 with BSI, 25 with viral infection

SUBMITTER: Butler JM 

PROVIDER: S-EPMC12182767 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature