AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling.

ABSTRACT:

Abstract

Acute graft-versus-host disease (GVHD) that occurs after allogeneic hematopoietic cell transplantation (allo-HCT) can affect the central nervous system (CNS). Most patients who have undergone allo-HCT receive antibiotic treatment, which alters the microbiome and essential microbiome-derived metabolites. We investigated the impact of microbiome modifications on CNS GVHD and therapeutic strategies to overcome the microbiome-derived metabolite depletion. Antibiotic treatment of mice undergoing allo-HCT increased microglia numbers in the brain, indicating increased inflammation. In addition, microglial morphology shifted toward a highly branched phenotype. Consistent with a proinflammatory phenotype, the microglia exhibited increased NF-κB and Src activity. Antibiotic treatmen

SUBMITTER: Zahringer A 

PROVIDER: S-EPMC12182783 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature