Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis.

ABSTRACT:

Introduction and aims

Carnitine palmitoyltransferase I (CPT1), the rate-limiting enzyme of fatty acid oxidation, plays a crucial role in inflammation. However, the relation between CPT1 and periodontitis is obscure. This study aimed to reveal the expression pattern of CPT1 (CPT1A, CPT1B, CPT1C) in periodontitis and their correlation with clinical parameters.

Methods

The public dataset was used to identify biological processes related to lipid metabolism and validate the differential expression of CPT1 between healthy and periodontitis groups. Forty-seven healthy gingival samples and 47 periodontitis gingival samples were gathered. Subsequently, real-time quantitative polymerase chain reaction was used to measure CPT1 expression. Their protein levels were assessed using weste

SUBMITTER: Shen Y 

PROVIDER: S-EPMC12182796 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature